Journal
CLINICAL AUTONOMIC RESEARCH
Volume 16, Issue 1, Pages 6-11Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s10286-006-0276-0
Keywords
insula; cardiac arrhythmias; stroke; sudden death
Categories
Funding
- NCRR NIH HHS [RR 00052, M01 RR000052] Funding Source: Medline
- NINDS NIH HHS [NS 33770] Funding Source: Medline
Ask authors/readers for more resources
That the brain may be involved in cardiovascular regulation has been acknowledged for over a century. That cardiac arrhythmias may result from cortical derangement has been less well recognized. That cortical cardiac representation may be lateralized is even more controversial. Recent evidence implicates several cortical structures, especially the insula, in cardiac rate and rhythm control. Experimental models indicate that insular lesions maybe arrhythmogenic. Accumulating data show similar lesion effects in humans. In the rat, monkey and man sympathetic cardiovascular control is generally represented in the right insula, although pronounced insulo-insular connectivity has been demonstrated. Proarrhythmic shifts in cardiac sympathovagal balance occur after human stroke, including left insular lesions. This evidence implicates the cortex in the promotion and even generation of cardiovascular dysfunction under appropriate circumstances.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available