Journal
DRUG RESISTANCE UPDATES
Volume 9, Issue 1-2, Pages 74-86Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.drup.2006.04.003
Keywords
microtubule; microtubule-targeting agents; endothelial cells; angiogenesis; metronomic chemotherapy
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Angiogenesis is a key event of tumor progression and metastasis and hence a target for cancer chemotherapy. Therapeutic strategies focused on angiogenesis include the discovery of new, targeted anti-angiogenic agents and the re-evaluation of conventional anti-cancer drugs. Here, we review the most recent studies investigating the molecular and cellular mechanisms responsible for the anti-angiogenic activity of microtubule-targeting agents (MTAs). These agents include some of the most widely used and effective antitumor drugs that are also among the most anti-angiogenic. In addition, we summarize the latest results of pre-clinical and clinical studies involving MTAs administered at low metronomic doses and in anti-angiogenic combination strategies. Finally, we discuss the future development of these agents, their clinical potential and their limitations. (c) 2006 Elsevier Ltd. All rights reserved.
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