Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 6, Issue 2, Pages 203-210Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955706775475984
Keywords
lymphatic filariasis; onchocerciasis; Wolbachia; tetracycline; doxycycline
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Wolbachia endosymbionts of filariae are targets for the development of new antifilarial chemotherapy. Doxycycline to deplete Wolbachia from the worm has demonstrated the feasibility of this strategy and has provided a new chemotherapeutic tool. Recent research shows that depleting Wolbachia will also lessen pathology, and lessen adverse reactions to traditional antifilarial drugs.
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