Journal
JOURNAL OF UROLOGY
Volume 175, Issue 2, Pages 619-623Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0022-5347(05)00233-8
Keywords
prostatitis; pelvic pain; cohort studies; prospective studies; quality of life
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Funding
- NIDDK NIH HHS [U01 DK53736, U01 DK53732, U01 DK53752, U01 DK53730, U01 DK53746, T32 DK060455, U01 DK53734, U01 DK53738] Funding Source: Medline
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Purpose: We present the results of 2 years of symptom and quality of life followup of men with CP/CPPS enrolled in the CPC. Materials and Methods: We followed 445 subjects from 6 clinical centers across North America for 2 years with outcome measures that included the NIH-CPSI, quality of life, and GRA. All subjects were treated according to usual care practices at each clinical site. Results: Of the 445 subjects 293 had complete data at 2 years. Withdrawals were younger, had been diagnosed more recently and had higher baseline symptoms. Among the 293 men the mean improvement at 2 years was 5 points on the 43-point NIH-CPSI total score. Most of the observed improvement occurred in the first 3 months of followup. Among all 445 subjects, retaining withdrawals in the denominator, 31% considered themselves moderately or markedly improved at :2 years. Although group mean symptom scores were stable and improved slightly over time, some individual subjects reported large fluctuations. No baseline demographic or clinical factors significantly predicted changes in symptom scores over time. Conclusions: CP/CPPS is a chronic disease characterized by substantial variation in symptoms within and among subjects. There is no evidence that the disorder worsens significantly during 2 years of followup, and for about a third of men with long-standing symptoms there may be moderate to marked improvement during this period.
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