Journal
FEMS MICROBIOLOGY LETTERS
Volume 255, Issue 2, Pages 275-279Publisher
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2005.00084.x
Keywords
transcription profiling; microarray analysis; aflatoxin; secondary metabolism; Aspergillus flavus; Aspergillus parasiticus
Categories
Ask authors/readers for more resources
Aflatoxin contamination of food and feed is a major concern due to the carcinogenic properties of this mycotoxin. Previous studies using classical approaches have identified a cluster of genes responsible for aflatoxin production under the control of the pathway-specific transcriptional regulator aflR, but it is unknown whether aflR controls expression of other genes within the genome. Transcription profiling comparing wild type and Delta aflR strains of Aspergillus parasiticus grown under conditions conducive for aflatoxin production identified only 23 upregulated genes in the wild type. These included 20 genes in the aflatoxin biosynthetic cluster, and three additional genes outside the aflatoxin biosynthetic cluster (nadA, hlyC, and niiA), all with AflR binding sites. This report is the first to demonstrate genes outside the biosynthetic cluster as being associated with aflR expression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available