Journal
TRENDS IN NEUROSCIENCES
Volume 29, Issue 2, Pages 116-124Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2005.12.006
Keywords
-
Categories
Funding
- NIDA NIH HHS [R01 DA015718-03, R01-DA015718, R01 DA015718] Funding Source: Medline
- NIDCD NIH HHS [T32-DC00054, T32 DC000054] Funding Source: Medline
- NINDS NIH HHS [T32-NS07375, T32 NS007375] Funding Source: Medline
Ask authors/readers for more resources
The orbitofrontal cortex, as a part of prefrontal cortex, is implicated in executive function. However, within this broad region, the orbitofrontal cortex is distinguished by its unique pattern of connections with crucial subcortical associative learning nodes, such as basolateral amygdala and nucleus accumbens. By virtue of these connections, the orbitofrontal cortex is uniquely positioned to use associative information to project into the future, and to use the value of perceived or expected outcomes to guide decisions. This review will discuss recent evidence that supports this proposal and will examine evidence that loss of this signal, as the result of drug-induced changes in these brain circuits, might account for the maladaptive decision-making that characterizes drug addiction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available