Journal
JOURNAL OF ANTIBIOTICS
Volume 59, Issue 2, Pages 105-109Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2006.15
Keywords
fluostatin; kinamycin; structure elucidation
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Three new fluostatin antibiotics have been isolated from the culture filtrate of Streptomyces strain Acta 1383. The chemical structures of these compounds were determined by mass spectrometry and NMR spectroscopy. The relative configuration has been determined by X-ray crystal structure analysis and the absolute configuration was deduced from NMR data with the help of Helmchen esters. These compounds represent the first reported epoxide fluostatins (1, 2) and underline previously found analogies to the group of kinamycin antibiotics.
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