Journal
PLOS BIOLOGY
Volume 4, Issue 2, Pages 258-270Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.0040022
Keywords
-
Categories
Funding
- NIBIB NIH HHS [R01 EB003832, EB/003832] Funding Source: Medline
- NINDS NIH HHS [NS/041096, NS/043300, R01 NS043300, R01 NS025907, NS/025907] Funding Source: Medline
Ask authors/readers for more resources
A highly interconnected network of arterioles overlies mammalian cortex to route blood to the cortical mantle. Here we test if this angioarchitecture can ensure that the supply of blood is redistributed after vascular occlusion. We use rodent parietal cortex as a model system and image the flow of red blood cells in individual microvessels. Changes in flow are quantified in response to photothrombotic occlusions to individual pial arterioles as well as to physical occlusions of the middle cerebral artery (MCA), the primary source of blood to this network. We observe that perfusion is rapidly reestablished at the first branch downstream from a photothrombotic occlusion through a reversal in flow in one vessel. More distal downstream arterioles also show reversals in flow. Further, occlusion of the MCA leads to reversals in flow through approximately half of the downstream but distant arterioles. Thus the cortical arteriolar network supports collateral flow that may mitigate the effects of vessel obstruction, as may occur secondary to neurovascular pathology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available