Journal
ENDOCRINE JOURNAL
Volume 53, Issue 1, Pages 111-117Publisher
JAPAN ENDOCRINE SOCIETY
DOI: 10.1507/endocrj.53.111
Keywords
bilateral adrenal tumor; Cushing's syndrome; adrenalectomy; hypercalcemia
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We report a rare case of ACTH-independent macronodular adrenal hyperplasia (AIMAH) with primary hyperparathyroidism (PHPT). A 57-year-old woman was admitted to our hospital for further examination of secondary hypertension and bilateral adrenal macrotumors. Midnight serum cortisol elevation with undetectable plasma ACTH, increased 24-hour urinary free cortisol excretion, and loss of the normal circadian rhythm in cortisol secretion established the diagnosis of Cushing's syndrome. Total resection of the enlarged left adrenal gland was performed with subsequent steroid replacement. Her general condition improved but serum calcium level increased 3 weeks after surgery. PHPT was diagnosed oil the basis of endocrinological examination, although imaging studies failed to detect parathyroid lesion. In Summary, we believe this to be the first report of a case of AIMAH with PHPT.
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