Journal
SEMINARS IN CANCER BIOLOGY
Volume 16, Issue 1, Pages 53-65Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2005.07.005
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Growing tumors acquire the ability to resist immune recognition and immune-mediated injury. Among several mechanisms, mouse and human tumors share the ability to alter the normal hematopoiesis, leading to accumulation of cells of the myelo-monoctytic lineage at the tumor site and in different primary and secondary lymphoid organs. These cells aid tumor development by providing molecules and factors essential for tumor growth and neovascularization but also exert a profound inhibitory activity on both tumor-specific and nonspecific T lymphocytes. The present article summarizes recent findings on the interaction between developing cancers and these recently described myeloid suppressor cells. (c) 2005 Elsevier Ltd. All rights reserved.
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