Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 100, Issue 2, Pages 162-166Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.SC0040188
Keywords
heme oxygenase-1; oxidized low-density lipoprotein; monocyte chemoattractant protein-1
Categories
Ask authors/readers for more resources
Heme oxygenase-1 (HO-1) is a stress-inducible isoform of HO with potential cytoprotective effects. Monocyte activation/migration mediated by monocyte chemoattractant protein-1 (MCP-1) is one of the earliest and important events in the pathogenesis of atherosclerosis. We examined the effect of HO-1 on the production of lysophosphatidylcholine (Lyso-PC)-induced MCP-1 in the human promonocytic cell line U937. Increased HO-I induction by hemin resulted in a significant decrease in the Lyso-PC-mediated induction of MCP-1 mRNA expression. SnPP (IX), the specific inhibitor of HO-1 enzymatic activity, prevented the hemin-mediated attenuation of MCP-1 mRNA expression. These results suggest that HO-1 may work as an anti-atherogenic agent through the attenuation of MCP-1 production.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available