Journal
PSYCHOPHARMACOLOGY
Volume 184, Issue 3-4, Pages 637-644Publisher
SPRINGER
DOI: 10.1007/s00213-005-0184-3
Keywords
transdermal nicotine replacement; withdrawal; smoking cessation
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Rationale: Decreasing withdrawal and craving during smoking cessation is a major aim of cessation medications. Prior studies have shown that Nicotine Replacement Therapy (NRT) decreases withdrawal symptom severity but have relied on retrospective reports and lacked robust measures of baseline symptoms or symptoms during unmedicated abstinence. Objectives and methods: We tested the effect of high-dose (35 mg) nicotine patch on withdrawal and craving during abstinence using real-time assessment with electronic diaries during ad libitum smoking, a brief period of experimentally directed trial abstinence, and the first 3 days of cessation. Subjects were 324 smokers randomized to high-dose nicotine patches or placebo. Results: Treatment with active patches reduced withdrawal and craving during cessation and completely eliminated deprivation-related changes in affect or concentration. Conclusion: High-dose NRT reduces withdrawal symptoms and craving and can eliminate some symptoms entirely.
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