Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 18, Issue 1, Pages 85-91Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2005.11.003
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Cross-presentation is the process whereby bone-marrow-derived antigen-presenting cells acquire, process and present exogenous antigen as peptides bound to MHC class I molecules to CD8(+) T cells. Professional antigen-presenting cells acquire cell-associated antigen predominantly in the form of protein, then process and present antigenic peptides on their surface MHC class I molecules via several mechanisms and efficiently cross-prime naive CD8(+) T cells in vivo. This pathway is of considerable interest because it has an important role in the immune surveillance of tissues for pathogens and cancers.
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