Journal
PHYSIOLOGY
Volume 21, Issue -, Pages 61-68Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00139.2005
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Funding
- NHLBI NIH HHS [HL-08010, R01 HL080810-02, R01 HL080810] Funding Source: Medline
- NIDDK NIH HHS [R01 DK61168, R01 DK-51610] Funding Source: Medline
- NIGMS NIH HHS [F32-GM-67424] Funding Source: Medline
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Ste20 serine/threonine kinases regulate fundamental cellular processes including the cell cycle, apoptosis, and stress responses. Recent studies in Caenorhabditis elegans and mammals demonstrate that Ste20 kinases also function in cell volume sensing and Cl- transport regulation. Yeast Ste20 initiates a shrinkage activated MAPK cascade that regulates organic osmolyte accumulation. Ste20 kinases thus play evolutionarily conserved roles in cellular volume sensing and regulation. They may also function in systemic osmotic homeostasis and to link cell-cycle events with cell volume.
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