Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 7, Issue 2, Pages 85-96Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1837
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Funding
- NIDDK NIH HHS [R01 DK031036] Funding Source: Medline
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Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.
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