Journal
SEMINARS IN THROMBOSIS AND HEMOSTASIS
Volume 32, Issue 1, Pages 5-10Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-2006-933335
Keywords
tissue factor; hemostasis; thrombosis; procoagulant; anticoagulant
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Tissue factor (TF) plays all essential role in hemostasis. The tissue-specific pattern of TF expression is consistent with additional hemostatic protection in vital organs. An aberrant expression of TF within the vasculature Occurs in a variety of diseases, including atherosclerosis, cancer, and sepsis. TF expression in these diseases is associated with thrombotic events. Future therapeutic strategies may prove beneficial in the treatment of thrombosis. However, these strategies should be designed to avoid compromising hemostasis.
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