Associations of plasma 8-isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease

Oxidative stress may play a role in the development of atherosclerosis. The purpose of the present study was to explore the relationship between 8-isoprostaglandin F-2 alpha (8-iso-PGF(2 alpha)) levels and the presence of coronary artery disease (CAD) and to also clarify whether 8-isoPGF(2 alpha) might add independently to measures of CAD extent. The study group consisted of 241 consecutive patients who were undergoing coronary angiography for suspected CAD. 8-iso-PGF(2 alpha) levels were recorded for all participants. The analysis revealed a significant difference in 8-iso-PGF(2 alpha) levels in patients with and without hypertension (P < 0.001), in patients with diabetes relative to nondiabetic patients (P < 0.05), and in males respect to females (P < 0.001). A significant positive correlation was found between age and 8-iso-PGF(2 alpha) levels (P < 0.001). 8-iso-PGF(2 alpha) levels correlated with the number of cardiovascular risk factors (P < 0.001). 8-iso-PGF(2 alpha) levels were higher in the CAD(+) respect to the CAD(-) groups (37.7 +/- 80.2 and 263.8 +/- 74.2 pg/ml and P < 0.001). A stepwise elevation in the 8-iso-PGF(2 alpha) levels was found depending on the number of affected vessels (P < 0.001). The 8-iso-PGF(2 alpha) levels showed a significant positive correlation with the numbers of > 50 and > 25% stenotic segments (P < 0.001) and the extent score of coronary stenosis (P < 0.001). The multivariate logistic regression analysis indicated 8-iso-PGF2. as an independent factor associated with CAD (odds ratio, 2.47 and P=0.001). The results suggested that 8-iso-PGF(2 alpha) is associated with the presence of CAD in patients undergoing coronary angiography and is also related to the extent of coronary stenosis in Chinese population. (c) 2005 Elsevier Ireland Ltd. All rights reserved.