Journal
APPLIED RADIATION AND ISOTOPES
Volume 64, Issue 2, Pages 194-200Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2005.07.019
Keywords
technetium-99m; [D-Phe(1),Tyr(3)]-octreotide; radiochemical purity; HPLC; TLC
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[(99m)-Tc-EDDA-HYNIC-D-Phe(1),Tyr(3)]-octreotide (Tc-99m-EDDA-HYNIC-TOC) is an alternative radioligand for somatostatin receptor (SSTR) scintigraphy of neuroendocrine tumours. In order to allow a rapid and accurate determination of the quality in the clinical routine the aim of this study was to evaluate different methods of radiochemical purity (RCP) testing. Three different methods of RCP testing were compared: high-performance liquid chromatograhpy (HPLC), thin layer chromatography (TLC) and minicolumn (Sep-Pak purification = SPE). HPLC was shown to be the most effective method for the quality control. The use of TLC and SPE is only recommended after sufficient practical labelling experience. (c) 2005 Elsevier Ltd. All rights reserved.
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