Journal
BIOMACROMOLECULES
Volume 7, Issue 2, Pages 415-418Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm050837s
Keywords
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Funding
- NHLBI NIH HHS [HL 62244, R01 HL052622, HL 52622, R01 HL062244] Funding Source: Medline
- NIGMS NIH HHS [GM 38060, R01 GM038060] Funding Source: Medline
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Electrospinning is a versatile process used to prepare micro- and nano- sized fibers from various polymers dissolved in volatile solvents. In this report, cellulose and cellulose-heparin composite fibers are prepared from nonvolatile room temperature ionic liquid (RTIL) solvents by electrospinning. RTILs are extracted from the biopolymer fiber after the fiber formation using a cosolvent. Micron to nanometer sized, branched fibers were obtained from 10% (w/w) concentration of polysaccharide biopolymer in RTIL solution with an applied voltage of 15-20 kV. Cellulose-heparin composite fibers showed anticoagulant activity, demonstrating that the bioactivity of heparin remained unaffected even on exposure to a high voltage involved in electrospinning.
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