Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 16, Issue 3, Pages 722-726Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.10.014
Keywords
glycogen phosphorylase; inhibitor; maslinic acid; derivatives; synthesis; SAR
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The synthesis of a series of maslinic acid derivatives is described and their effect on rabbit muscle glycogen phosphorylase a evaluated. Within this series of compounds, 15 (IC50 = 7 mu M) is the most potent GPa inhibitor. SAR of the maslinic acid derivatives are discussed. (c) 2005 Elsevier Ltd. All rights reserved.
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