Journal
NEUROBIOLOGY OF DISEASE
Volume 21, Issue 2, Pages 256-275Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2005.07.004
Keywords
apolipoprotein E; Alzheimer disease; gene expression; microarray; apoptosis; signal pathways
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Funding
- NIA NIH HHS [AG19085, AG13308, AG11268] Funding Source: Medline
- NIMH NIH HHS [MH59528, MH52453] Funding Source: Medline
- NINDS NIH HHS [NS3 9764, NS031 153, NS31 153] Funding Source: Medline
- PHS HHS [AGIO123] Funding Source: Medline
- Wellcome Trust [AG05 128] Funding Source: Medline
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Apolipoprotein E4 (APOE4) allele is a major risk factor for late-onset familial and sporadic Alzheimer disease (AD). The mechanism of action of APOE in the etiology of AD remains unclear. Using gene expression (microarray) analysis of human hippocampus from APOE3/ 3 AD and APOE4/4 AD cases, we found different gene transcription patterns between APOE4/4 and APOE3/3 AD cases. The expression of APOE4/4 alleles, in comparison to APOE3/3, is associated with upregulation of multiple gene transcripts encoding cell growth suppresser or arrest, signal transduction, myelinogenesis, cell adhesion and migration, heavy metal metabolism and detoxification. Whereas the APOE4 gene expression is associated with downregulation of gene transcripts involved in mitochondrial oxidative phosphorylation and energy metabolism, synaptic vesicle docking and fusing, and synaptic plasticity compared to APOE3. These mechanisms may contribute increased risk for AD and for cognitive dysfunction in AD patients who carry the APOE4 allele(s). (c) 2005 Elsevier Inc. All rights reserved.
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