Journal
TOXICOLOGICAL SCIENCES
Volume 89, Issue 2, Pages 352-360Publisher
OXFORD UNIV PRESS
DOI: 10.1093/toxsci/kfj018
Keywords
toxicogenomics; risk assessment
Categories
Funding
- NIEHS NIH HHS [R01-ES12245, R01-ES011271, P42-ES04911] Funding Source: Medline
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Since its inception, there have been high expectations for the science of toxicogenomics to decrease the uncertainties associated with the risk assessment process by providing valuable insights into toxic mechanisms of action. However, the application of these data into risk assessment practices is still in the early stages of development, and proof of principle experiments have yet to emerge. The following discusses some potential applications as well as impediments that warrant a concerted investigation from all stakeholders in order to facilitate the acceptance and subsequent incorporation of toxicogenomics into regulatory decision making.
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