Journal
ANNALS OF THE RHEUMATIC DISEASES
Volume 72, Issue 10, Pages 1594-1604Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/annrheumdis-2013-203631
Keywords
Knee Osteoarthritis; Magnetic Resonance Imaging; Outcomes research
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Funding
- European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
- Medical Research Council [U1475000001, MC_UP_A620_1014, MC_UU_12011/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10082] Funding Source: researchfish
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Knee osteoarthritis is associated with structural changes in the joint. Despite its many drawbacks, radiography is the current standard for evaluating joint structure in trials of potential disease-modifying osteoarthritis drugs. MRI is a non-invasive alternative that provides comprehensive imaging of the whole joint. Frequently used MRI measurements in knee osteoarthritis are cartilage volume and thickness; others include synovitis, synovial fluid effusions, bone marrow lesions (BML) and meniscal damage. Joint replacement is considered a clinically relevant outcome in knee osteoarthritis; however, its utility in clinical trials is limited. An alternative is virtual knee replacement on the basis of symptoms and structural damage. MRI may prove to be a good alternative to radiography in definitions of knee replacement. One of the MRI parameters that predicts knee replacement is medial compartment cartilage volume/thickness, which correlates with radiographic joint space width, is sensitive to change, and predicts outcomes in a continuous manner. Other MRI parameters include BML and meniscal lesions. MRI appears to be a viable alternative to radiography for the evaluation of structural changes in knee osteoarthritis and prediction of joint replacement.
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