Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 18, Issue 1, Pages 31-38Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2005.11.007
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Funding
- NEI NIH HHS [R03EY015840] Funding Source: Medline
- NHLBI NIH HHS [R01HL65410] Funding Source: Medline
- NIAID NIH HHS [R01AI44920, R01AI40611, R21AI063400] Funding Source: Medline
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Many researchers believe that gamma delta T lymphocytes belong somewhere 'in-between' the innate and adaptive immune systems. Recent studies strongly emphasize the innate features and functions of these cells, including the use of germline elements of the T cell receptor for ligand recognition, segregation into functionally specialized cell populations in correlation with T cell receptor variable gene or protein expression, interactions with cells of the innate system at many levels and, the latest addition, the ability to present antigen. Thus, at present, much evidence suggests that gamma delta T cells function in an innate manner, although they are arguably the most complex and advanced cellular representatives of the innate immune system.
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