Journal
NUTRITIONAL NEUROSCIENCE
Volume 9, Issue 1-2, Pages 57-61Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10284150600637739
Keywords
antioxidant; catechins; cerebrospinal fluid; flavan-3-ols; green tea
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Following acute ingestion of green tea by six human subjects, HPLC-MS 2 analysis revealed that flavan-3-ol methyl, glucuronide and sulfate metabolites appeared in the bloodstream but did not pass through the blood-cerebrospinal fluid barrier. These observations emphasize the discrepancies between in vitro and in vivo evidence on the neuroprotective role of these compounds. If, as has been proposed, green tea exerts neuroprotective effects, this finding indicates that the active components are not flavan-3-ols or their metabolites. Alternatively, a systemic action may be hypothesised whereby dietary flavan-3-ols up-regulate antioxidant defences and/or reduce inflammation, the benefit of which may be effective throughout the body.
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