Journal
HEREDITY
Volume 96, Issue 2, Pages 195-202Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.hdy.6800789
Keywords
RNAi; TGS; PTGS; silencing; transposons; viruses; genome stability
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RNA silencing is a form of nucleic-acid-based immunity, targeting viruses and genomic repeated sequences. First documented in plants and invertebrate animals, this host defence has recently been identified in mammals. RNAi is viewed as a conserved ancient mechanism protecting genomes from nucleic acid invaders. However, these tamed sequences are known to occasionally escape this host surveillance and invade the genome of their host. This response is consistent with the overall idea that parasitic sequences compete with cells to systematically counter host defences. Using examples taken from the current literature, we illustrate the dynamic move - countermove game played between these two protagonists, the host cell and its parasitic sequences, and discuss the consequences of this game on genome stability.
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