Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 16, Issue 1, Pages 51-59Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2005.12.007
Keywords
-
Categories
Ask authors/readers for more resources
Controlled regulation of cell proliferation and differentiation is essential for embryonic development and requires the coordinated regulation of cell-cell adhesion and gene transcription. The armadillo repeat protein beta-catenin is an important integrator of both processes. beta-catenin acts in the Writ signaling pathway, activating the transcription of crucial target genes responsible for cellular proliferation and differentiation. beta-catenin also controls E-cadherin-mediated cell adhesion at the plasma membrane and mediates the interplay of adherens junction molecules with the actin cytoskeleton. Both functions of beta-catenin are de-regulated in human malignancies, thereby leading both to the loss of cell-cell adhesion and to the increased transcription of Wnt target genes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available