Journal
PHYSIOLOGY
Volume 21, Issue -, Pages 38-47Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00042.2005
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Funding
- NIMH NIH HHS [R01 MH087823, R01 MH050861] Funding Source: Medline
- NINDS NIH HHS [R01 NS037311] Funding Source: Medline
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Dendritic spines are small protrusions from neuronal dendrites that form the postsynaptic component of most excitatory synapses in the brain. They play critical roles in synaptic transmission and plasticity. Recent advances in imaging and molecular technologies reveal that spines are complex, dynamic structures that contain a dense array of cytoskeletal, transmembrane, and scaffolding molecules. Several neurological and psychiatric disorders exhibit dendritic spine abnormalities.
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