Journal
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Volume 46, Issue 1, Pages 85-99Publisher
WILEY
DOI: 10.1111/j.1574-695X.2005.00004.x
Keywords
lipopolysaccharide structure; core oligosaccharide; O-unit; O-antigen; Pseudomonas aeruginosa
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Funding
- NIAID NIH HHS [AI 22535] Funding Source: Medline
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Highly phosphorylated core oligosaccharides and those substituted with one O-antigen repeating unit were obtained by mild acid degradation or strong alkaline hydrolysis of lipopolysaccharide samples from 23 reference strains representing all Pseudomonas aeruginosa O-serogroups. Studies by high-resolution electrospray ionization mass spectrometry and two-dimensional NMR spectroscopy revealed both conserved and variable structural features of the lipopolysaccharides of various O-serogroups. The upstream terminal saccharide of the O-antigen, which contributes most to the immunospecificity of the bacteria, was defined in 11 from a total of 13 O-serogroups. The data obtained link together the known biosynthesis pathways, genetics and serology of the P. aeruginosa lipopolysaccharide.
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