Journal
ORGANIC LETTERS
Volume 8, Issue 3, Pages 415-418Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol052552y
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alpha-Carbolines are interesting core structures for designing DNA-interacting small molecules. However, these compounds are not commercially available and their synthetic methods are low yielding or time consuming. The shortest synthetic route, the modified Graebe-Ullmann reaction, has been optimized by using microwave heating in four different types of apparatus to give shorter reaction times and enhanced yields. Optimized conditions enabled the preparation of a small library of alpha-carbolines.
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