Journal
CIRCULATION RESEARCH
Volume 98, Issue 2, Pages 186-191Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.RES.0000200177.53882.c3
Keywords
Egr-1; atherosclerosis; vascular injury; angiogenesis; ischemia and ischemia-reperfusion; allograft rejection; cardiac hypertrophy
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The immediate-early gene product and zinc finger transcription factor early growth response (Egr)-1 plays a key master regulatory role in multiple cardiovascular pathological processes. This article reviews the amassing recent evidence implicating Egr-1 in atherosclerosis, intimal thickening after acute vascular injury, ischemic pathology, angiogenesis, allograft rejection, and cardiac hypertrophy.
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