Journal
ANALYTICA CHIMICA ACTA
Volume 558, Issue 1-2, Pages 296-301Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2005.10.081
Keywords
chemiluminescence; naproxen; urine; flow injection analysis
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Based on the synergic effect of the hydrophobicity of sodium dodecylbenzenesulfonate (SDBS) micelles and the incorporation of naproxen molecules, a simple, rapid and sensitive chemiluminescence (CL) method was described for the determination of naproxen in pharmaceuticals and urine. Under the optimum experimental conditions, the CL intensity was linear over the concentration of naproxen ranging from 1.0 to 700.0 ng mL(-1) (r = 0.9917) with a detection limit as low as 0.9 ng mL(-1) (S/N = 3). The mechanism of CL was discussed in detail based on the spectrometry. The experimental results demonstrated that the excretive amounts of naproxen reached its maximum in 4.0 h after taking 200 mg naproxen tablet; and the naproxen excretive ratio during 8.0 h was 5.46% in the body of volunteers. (c) 2005 Elsevier B.V. All rights reserved.
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