Journal
FEBS LETTERS
Volume 580, Issue 3, Pages 862-866Publisher
WILEY
DOI: 10.1016/j.febslet.2005.12.104
Keywords
cytochrome c oxidase subunit II (cox2); DUI; C-terminus extension; Unionoidea; Venustaconcha ellipsiformis
Funding
- NICHD NIH HHS [HD38520] Funding Source: Medline
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Analyses of unionoidean bivalve male-transmitted (M) mtDNA genomes revealed an approximately 555 lip 3' coding extension to cox2. An antibody was generated against this predicted C-terminus extension to determine if the unique cox2 protein is expressed. Western blot and immunohistochemistry analyses demonstrated that the protein was predominantly expressed in testes. Weak expression was detected in other male tissues but the protein was not detected in female tissues. This is the first report documenting the expression of a cox2 protein with a long C-terminus in animals. Its universal presence in unionoidean bivalve testes suggests a functional significance for the protein. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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