Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 6, Pages 1675-1680Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0506135103
Keywords
mathematical model
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Funding
- NHLBI NIH HHS [HL71930, R01 HL071930] Funding Source: Medline
- NIDCR NIH HHS [R56 DE014756, DE14756, R01 DE014756] Funding Source: Medline
- NIDDK NIH HHS [R01 DK054568, R56 DK054568, DK54568] Funding Source: Medline
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In some cell types, oscillations in the concentration of free intracellular calcium ([Ca2+]) are accompanied by oscillations in the concentration of inositol 1,4,5-trisphosphate ([IP3]). However, in most cell types it is still an open question as to whether oscillations in [IP3] are necessary for Ca2+ oscillations in vivo, or whether they merely follow passively. Using a wide range of models, we show that the response to an artificially applied pulse Of IN can be used to distinguish between these two cases. Hence, we show that muscarinic receptor-mediated, long-period Ca2+ oscillations in pancreatic acinar cells depend on [IP3] oscillations, whereas short-period Ca2+ oscillations in airway smooth muscle do not.
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