Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 6, Pages 1840-1845Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0509228103
Keywords
apoptosis; tumor necrosis factor; MCF-7 cells; estrogen receptor
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Funding
- NIAID NIH HHS [AI 15136, U54 AI054523, R01 AI015136, U54 AI54523] Funding Source: Medline
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Nod1, a cytosolic protein that senses meso-diaminopimelic acid-containing ligands derived from pepticloglycan, plays a role in host responses to invasive bacteria. Here we describe a function for Nod1, whereby it controls tumor formation. Cell lines derived from the human breast cancer epithelial cell line MCF-7 were used in a severe combined immune deficiency (SCID) mouse xenograft model to characterize a pathway linking Nod1 to the growth of estrogen-sensitive tumors. In MCF-7 cells, the absence of Nod1 correlates with tumor growth, an increased sensitivity to estrogen-induced cell proliferation, and a failure to undergo Nod1-dependent apoptosis. Conversely, overexpression of Nodl in MCF-7 cells results in inhibition of estrogen-dependent tumor growth and reduction of estrogen-induced proliferative responses in vitro.
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