Journal
ANNALS OF THE RHEUMATIC DISEASES
Volume 72, Issue 12, Pages 2006-2010Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/annrheumdis-2012-202800
Keywords
Hand Osteoarthritis; Osteoarthritis; Epidemiology
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Funding
- German Society of Rheumatology
- Austrian Science Fund (FWF) [KLI123]
- Pfizer Articulum Fellowship
- Austrian Science Fund (FWF) [KLI123] Funding Source: Austrian Science Fund (FWF)
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Objectives The aim of this study was to assess the role of vascular adhesion molecule 1 (VCAM-1) in patients with hereditary haemochromatosis (HH) with or without arthropathy. Methods Sera from a large cross-sectional cohort of unselected HH patients (n=147) were obtained and compared to an age-matched and sex-matched control group. Serum levels of VCAM-1 were measured by ELISA and were correlated with clinical measures. Results VCAM-1 serum levels were elevated in HH patients as compared to matched controls (mean 913456 vs 654 +/- 451ng/ml, p<0.0001). Within the HH patient group, VCAM-1 levels were much higher in patients with arthropathy and joint replacement surgery. VCAM-1 levels correlated well with radiographic measures of HH arthropathy (r=0.36, p<0.0001). Multivariate regression analysis confirmed a highly significant association of VCAM-1 serum levels and the presence of HH arthropathy, independent from diabetes, body mass index and age. Conclusions VCAM-1 serum levels emerge as a biomarker for haemochromatosis arthropathy.
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