Journal
FEBS LETTERS
Volume 580, Issue 4, Pages 1017-1022Publisher
WILEY
DOI: 10.1016/j.febslet.2005.11.040
Keywords
prediction constrains; experiment-backed prediction; domain arrangement; transmembrane proteins
Ask authors/readers for more resources
In this review, we summarize the currently available information on the membrane topology of some key members of the human ABC protein subfamilies, and present the predicted domain arrangements. In the lack of high-resolution structures for eukaryotic ABC transporters this topology is based only on prediction algorithms and biochemical data for the location of various segments of the polypeptide chain, relative to the membrane. We suggest that topology models generated by the available prediction methods should only be used as guidelines to provide a basis of experimental strategies for the elucidation of the membrane topology. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available