Journal
BRITISH JOURNAL OF CANCER
Volume 94, Issue 3, Pages 341-345Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6602951
Keywords
tankyrase; poly(ADP-ribosyl) ation; telomeres; telomerase
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The requirement for the maintenance of telomeres by telomerase by most cancer cells for continued proliferation is a target in anticancer strategies. Tankyrases are poly(ADP-ribose) polymerases that enhance telomerase access to telomeres. Tankyrase I modulates telomerase inhibition in human cancer cells and is reviewed in this report as a potential telomere-directed anticancer target.
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