Journal
FEBS LETTERS
Volume 580, Issue 4, Pages 998-1009Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2005.12.060
Keywords
multidrug resistance; P-glycoprotein; MDR1; somatic cell genetics; transport; chemotherapy
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The discovery and characterization of P-glycoprotein, an energy-dependent multidrug efflux pump, as a mechanism of multidrug resistance in cancer is generally accepted as a significant contribution to the ongoing effort to end death and suffering from this disease. The historical reflections of Victor Ling and Michael Gottesman concerning the early years of this research highlight the important contributions of the multidisciplinary teams involved in these studies, and illustrate how technological developments in biochemistry and molecular and cell biology enabled this discovery. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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