4.7 Article

Fluorinase mediated C-18F bond formation, an enzymatic tool for PET labelling

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 6, Pages 652-654

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b516861a

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Funding

  1. Biotechnology and Biological Sciences Research Council [B19112, BBS/B/04579] Funding Source: researchfish
  2. Engineering and Physical Sciences Research Council [GR/S97491/01] Funding Source: researchfish
  3. Biotechnology and Biological Sciences Research Council [B19112, BBS/B/04579] Funding Source: Medline

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The fluorinase enzyme from S. cattleya is applied as a catalyst for the efficient incorporation of [F-18]-fluoride into [F-18]-5'-fluoro-5'-deoxyadenosine, [F-18]-5'-fluoro-5'-deoxyinosine and [F-18]-5-fluoro-5-deoxyribose for positron emission tomography (PET) applications.

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