Journal
TALANTA
Volume 68, Issue 4, Pages 1303-1308Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2005.07.043
Keywords
poly(ethylene terephthalate) (PET)-toner; microchip capillary electrophoresis; electrochemical detection; acetaminophen; p-aminophenol
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Rapid separation and determination of acetaminophen and its hydrolysate with end-channel electrochemical (EC) detection integrated on a plastified poly(ethylene terephthalate) (PET)-toner microchip capillary electrophoresis (CE) system was investigated. In this separation and detection system, a Pt ultramicroelectrode integrated on a three-dimensional adjustor was used as working electrode. Factors influencing the separation and detection were investigated and optimized. Results show that acetaminophen and p-aminophenol can be well separated within 84 s with R.S.D. < 1% for migration time and R.S.D. < 3.6% for detection current for both analytes. Detection limits for both analytes are determined to be 5.0 mu M (S/N = 3). This method has been successfully applied to the detection of trace p-aminophenol in paracetamol tablets. The results demonstrate that the PET-toner microchips can obtain better performance than PDMS microfluidic devices but at much lower cost. (c) 2005 Elsevier B.V. All rights reserved.
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