Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 14, Issue 4, Pages 1029-1038Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2005.09.020
Keywords
bridged nucleic acids; conformation; nucleosides; oligonucleotides
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A novel bridged nucleic acid (BNA) analogue, 2'-O,4'-C-methleneoxymethylene bridged nucleic acid (2',4'-BNA(COC)), was synthesized and incorporated into oligonucleotides. The 2',4'-BNA(COC) modified oligonucleotides showed high binding affinity with in RNA complement and significant enzymatic stability against snake venom phosphodiesterase. (c) 2005 Elsevier Ltd. All rights reserved.
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