Journal
BIOLOGICAL PSYCHIATRY
Volume 59, Issue 4, Pages 309-316Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2005.07.010
Keywords
cardiac; coronary artery disease; depression; heart rate variability; propranolol; rats; serotonin
Categories
Funding
- NCRR NIH HHS [S10RR016652] Funding Source: Medline
- NHLBI NIH HHS [HL14388, HL57472] Funding Source: Medline
- NIDDK NIH HHS [DK066086] Funding Source: Medline
- NIMH NIH HHS [MH65839] Funding Source: Medline
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Background: Depression has a complex bidirectional association with bean disease. Previously we have shown notable cardiovascular changes in the chronic mild stress (CMS) rodent model of depression. Here we investigated the effects of a serotonin-specific reuptake inhibitor on a behavioral index of depression (anhedonia) and cardiac function in rats exposed to CMS. Methods: Male Sprague-Dawley rats were exposed to either 4 weeks of control conditions or CMS, consisting of unpredictable periods Of mild stressors.. while being treated concurrently with 4 weeks of daily fluoxetine (10 mg/kg, sc) or vehicle. Results: Chronic fluoxetine treatment prevented anhedonia in rats exposed to CMS, versus the CMS group treated with vehicle. However; treatment with fluoxetine in the CMS group only partially prevented specific cardiovascular changes associated with CMS, including elevated resting heart rate (HR), exaggerated pressor and HR responses to an-jet stress, reduced cardiac output and stroke volume, and HR exaggerated responses to beta-adrenergic receptor blockade. Conclusions: These findings provide evidence that 4 weeks of fluoxetine treatment can prevent behavioral responses and can partially prevent cardiovascular changes associated with CMS, providing insight into the role of serotonin in the link between depression and cardiovascular dysfunction.
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