Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 40, Issue 4, Pages 721-733Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2005.09.026
Keywords
renal cell cancer; lipid peroxidation; apoptosis; VHL gene; hypoxia-inducible factors; oxidative stress; free radical
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We have recently proposed lipid peroxidation as a unifying mechanistic pathway by which several seemingly unrelated risk/protective factors (obesity, hypertension, diabetes, smoking, oophorectomy/hysterectomy, parity, antioxidants) affect renal cell carcinoma development. In experimental studies, increased lipid peroxidation is a principal mechanistic pathway in renal carcinogenesis induced by different chemicals. In this communication, we provide additional lines of evidence that further support a role for lipid peroxidation on renal cell cancer development. (1) Lipid peroxidation may explain the role of other risk (analgesic use, pre-eclampsia) or protective (alcohol intake, oral contraceptives) factors for renal cell carcinoma. (2) Additional experimental evidence supports lipid peroxidation as an important mechanism in renal carcinogenesis, and (3) Existing evidence support a cross-talk between the lipid peroxidation pathway and other pathways that are relevant to renal carcinogenesis, Such as apoptosis, VHL, and possibly other pathways. (c) 2005 Elsevier Inc. All rights reserved.
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