Journal
CELL CYCLE
Volume 5, Issue 4, Pages 384-391Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.5.4.2439
Keywords
centrosome; polarity; mitosis; attachment; cilia; Aurora-A; HEF1; Cas
Categories
Funding
- NCI NIH HHS [CA-06927, P30 CA006927, R01 CA063366-11, P30 CA006927-43, R01 CA063366, CA63366] Funding Source: Medline
Ask authors/readers for more resources
Regulated timing of cell division cycles, and geometrical precision in the planar orientation of cell division, are critical during organismal development and remain important for the maintenance of polarized structures in adults. Mounting evidence suggests that these processes are coordinated at the centrosome through the action of proteins that mediate both cell cycle and cell attachment. Our recent work identifying HEF1 as an activator of the Aurora A kinase suggests a novel hub for such integrated signaling. We suggest that defects in components of the machinery specifying the temporal and spatial integration of cell division may induce cancer and other diseases through pleiotropic effects on cell migration, proliferation, apoptosis, and genomic stability.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available