Journal
BIOLOGICAL PSYCHIATRY
Volume 59, Issue 4, Pages 334-340Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2005.07.027
Keywords
impulsivity; MAO-A; gene polymorphism; prefrontal cortex; Go/NoGo task; BOLD-fMRI
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Funding
- MRC [MC_U105579214] Funding Source: UKRI
- Medical Research Council [MC_U105579214] Funding Source: researchfish
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Background: Previous evidence has shown that genetic variations in The serotoneigic system contribute to individual differences in Personality traits germane to impulse control. The monoamine oxidase-A (MAO-A) gene, coding for an enzyme primarily involved in serotonin and noradrenaline catabolism, presents a well-characterized functional polymorphism consisting of a variable number of tandem repeats in the promoter region, with high-activity and low-activity variants. High-activity allele carriers have higher enzyme expression, lower anzine concentration, and present higher scores on behavioral measures of impulsivity than low-activity allele carriers. Methods: We studied the relationship of this polymorphism to brain activity elicited by a response inhibition task, (Go/NoGo task), using blood oxygenation level-dependent (BOLD),functional magnetic resonance imaging in 24 healthy men. Results: Direct comparison between groups revealed a greater BOLD response in the right ventrolateral prefrontal cortex (Brodmann's area [BA] 45/47) in high-activity allele carriers, whereas 61 greater response in the right superior parietal cortex (BA 7) and bilateral extrastriate cortex (BA 18) was found in low-activity allele carriers. Conclusions: These data suggest That a specific genetic variation involving serotonergic catabolism can modulate BOLD response associated with human impulsivity.
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