Journal
JOURNAL OF NEUROSCIENCE
Volume 26, Issue 8, Pages 2157-2166Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4070-05.2005
Keywords
oligodendrocytes; astrocytes; proliferation; spinal cord; injury; Schwann cell
Categories
Funding
- NINDS NIH HHS [NS047101, NS42291] Funding Source: Medline
Ask authors/readers for more resources
Neurogenesis has been described in various regions of the CNS throughout life. We examined the extent of natural cell division and replacement from 7 weeks to 7 months after cervical spinal cord injury in four adult rhesus monkeys. Bromodeoxyuridine ( BrdU) injections revealed an increase of > 80-fold in the number of newly divided cells in the primate spinal cord after injury, with an average of 725,000 BrdU-labeled cells identified per monkey in the immediate injury zone. By 7 months after injury, 15% of these new cells expressed mature markers of oligodendrocytes and 12% expressed mature astrocytic markers. Newly born oligodendrocytes were present in zones of injury-induced demyelination and appeared to ensheath or remyelinate host axons. Thus, cell replacement is an extensive natural compensatory response to injury in the primate spinal cord that contributes to neural repair and is a potential target for therapeutic enhancement.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available