Journal
ANALYTICA CHIMICA ACTA
Volume 560, Issue 1-2, Pages 191-196Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2005.12.011
Keywords
covalent immobilization; emulsion polymerization; fluorescence probe; 3-amino-9-ethylcarbazole (AEC); metronidazole
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A novel method of preparing fluorescence particle probe by emulsion polymerization with covalent immobilization of indicator dye was described. A terminal double bond was attached to 3-amino-9-ethylcarbazole (AEC) via methacryloyl chloride, and the resultant compound was copolymerized with butyl methacrylate. The obtained polymer particles were used as a fluorescence probe, which is almost free of dye leaching, and has higher photostability and lower toxicity in comparison with free AEC. This probe holds great potential for the applications in intracellular measurements. In present study the prepared probe was used for the determination of metronidazole. The results revealed that the probe showed good selectivity and had a linear response to the analyte in the range from 2.0 x 10(-5) to 1.0 X 10(-3) mol(-1) with a detection limit of 9.0 x 10(-6) Mol l(-1). (c) 2006 Published by Elsevier B.V.
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