Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 49, Issue 4, Pages 1235-1238Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm051200u
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The identification of a series of imidazo[1,2-b][1,2,4]triazines with high affinity and functional selectivity for the GABA(A) alpha 3-containing receptor subtype is described, leading to the identification of a clinical candidate, 11. Compound 11 shows good bioavailability and half-life in preclinical species, and it is a nonsedating anxiolytic in both rat and squirrel monkey behavioral models.
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