Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 40, Issue 3, Pages 571-580Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpba.2005.11.028
Keywords
UPLC; UPLC/MS; structural elucidation using deuterium exchange
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The beta-blockers Oxprenolol, Metoprolol, Acebutolol, Atenolol, Propranolol, Pindolol, and Alprenolol were analysed by both UPLC/MS and HPLC/MS using mobile phases containing acetonitrile, TFA and either H2O or D2O. UPLC gave superior separation performance and the quality of the mass spectra were at least as good as those from HPLC. (c) 2005 Elsevier B.V. All rights reserved.
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